Paper: The spatiotemporal distribution of human pathogens in ancient Eurasia

 Abstract

Infectious diseases have had devastating effects on human populations throughout history, but important questions about their origins and past dynamics remain1. To create an archaeogenetic-based spatiotemporal map of human pathogens, we screened shotgun-sequencing data from 1,313 ancient humans covering 37,000 years of Eurasian history. We demonstrate the widespread presence of ancient bacterial, viral and parasite DNA, identifying 5,486 individual hits against 492 species from 136 genera. Among those hits, 3,384 involve known human pathogens2, many of which had not previously been identified in ancient human remains. Grouping the ancient microbial species according to their likely reservoir and type of transmission, we find that most groups are identified throughout the entire sampling period. Zoonotic pathogens are only detected from around 6,500 years ago, peaking roughly 5,000 years ago, coinciding with the widespread domestication of livestock3. Our findings provide direct evidence that this lifestyle change resulted in an increased infectious disease burden. They also indicate that the spread of these pathogens increased substantially during subsequent millennia, coinciding with the pastoralist migrations from the Eurasian Steppe4,5.

Sikora, M., Canteri, E., Fernandez-Guerra, A. et al. The spatiotemporal distribution of human pathogens in ancient Eurasia. Nature 643, 1011–1019 (2025). https://doi.org/10.1038/s41586-025-09192-8

My source: Carl Zimmer. What has ailed us over time, The New York Times International Edition, July 30th 2025. p.12.

Science domain: Why upper Right?

individual

|

INTERPERSONAL : SCIENCES

humanistic ----------------------------------------------- mechanistic

SOCIOLOGY : POLITICAL

|

group - population

	"Scientists have theorised why DNA curls to the right. A study at New York University has found that when cosmic rays hit the atmosphere, they produce a cascade of cosmic particles. Among these are muons, which have a magnetic polarisation, which causes more right handed mutations, according to a paper in Astrophysical Journal Letters."
...

My source: News, The Times, 3 July, 2020, p.8.

What should be written in a HC Professional's DNA?

Before putting twitter down for a break, I was reminded about a form of DNA.

There are previous posts on the 6Cs in nursing here on W2tQ and taking these essential qualities as an obvious starting-point:

1. care,
2. compassion,
3. courage,
4. communication,
5. commitment
6. and competence

- and mapping them to the care (knowledge) domains of Hodges' model, you realise how they apply across the model. Care, Compassion and Communication are the essence of what it is to be human and humanistic. If however the time 'allowed', environment and accessibility are not attended to, then the mechanistic domains can disrupt the most caring of efforts.

What about courage? This is surely a very individual character trait? A personal quality in this context, with an emphasis on the humanistic domains.

Care is relational and we can consider courage in respect to scientific knowledge. As a member of the multidisciplinary team, or specialist practitioner a nurse may need courage to share scientific knowledge, evidence concerning genomics, for example. The public's knowledge and understanding of science is brought to the fore. There is the alternate scenario with the 'patient' as expert, for example in the case of rare diseases (especially next month).

Courage is a continua, that like strands of DNA runs through all the domains of Hodges' model and the 2020s ... will see the political realisation of courage in nursing and healthcare; locally, regionally, nationally and globally.

Reading (another) book for review, the authors draw attention to how Maslow's hierarchy says little, if anything, about altruism (but is implied?).

As these brief observations should demonstrate, Hodges' model facilitates relational, person-centredness, the cross-fertilization of ideas and high standards of care.

Who needs a double-helix when you can have a quadruple form?

individual

|

INTERPERSONAL : SCIENCES

humanistic ----------------------------------------------- mechanistic

SOCIOLOGY : POLITICAL

|

group - population

	Shankar Balasubramanian in front of a mural in his office representing quadruplex DNA, called ‘Living by the code’ by artist Annie Newman.

My source:
MindScience, Biochemistry, FT Magazine, FT Weekend. 26-27 January 2013, p.50.

Reminded via:

Thanks David, It's that last bit my focus (meme won't let go!)
individual and a collective 'mindset' all disciplines have from intro 101.
Professional DNA vital
*must* be preserved too [#AI]
*Rapid response calls for X-fertilization Quad-DNA?* ;-)https://t.co/CUuRsRPXl0#h2cm

— Peter Jones: 2020s will demand '2020' vision #h2cm (@h2cm) January 24, 2020

ERCIM News No. 82 Special theme "Computational Biology"

Dear ERCIM News Reader

ERCIM News No. 82 has just been published at http://ercim-news.ercim.eu/

Special Theme: "Computational Biology"

- coordinated by: Gunnar Klau, CWI, The Netherlands and Jacques Nicolas, INRIA, France

- featuring a keynote by Dirk J. Evers, Director, Computational Biology, Illumina, Inc.

Next issue: October 2010 - Special Theme: "Cloud Computing Platforms, Software, and Applications"

(see call for articles)

Thank you for your interest in ERCIM News.

Feel free to forward this message to others who might be interested.

Best regards,

Peter Kunz
ERCIM News central editor

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Of specific interest to me pages 59-60:

Graph Transformation for Consolidation of Creativity Sessions Results
by Peter Dolog
idSpace