Paper: Human social genomics i

Abstract

'The exciting field of human social genomics provides an evolutionarily informed, multilevel framework for understanding how positive and negative social–environmental experiences affect the genome to impact lifelong health, well-being, behavior, and longevity. In this review, we first summarize common patterns of socially influenced changes in the expression of pro-inflammatory and antiviral immune response genes (e.g., the Conserved Transcriptional Response to Adversity), and the multilevel psychological, neural, and cell signaling pathways by which social factors regulate human gene expression. Second, we examine how these effects are moderated by genetic polymorphisms and the specific types of social–environmental experiences that most strongly affect gene expression and health. Third, we identify positive psychosocial experiences and interventions that have been found to impact gene expression. Finally, we discuss promising opportunities for future research on this topic and how health care providers can use this information to improve patient health and well-being.'

Slavich GM, Mengelkoch S, Cole SW. Human social genomics: Concepts, mechanisms, and implications for health. Lifestyle Med. 2023; 4:e75. https://doi.org/10.1002/lim2.75
 

Lifestyle Medicine

For ongoing study of Hodges' model this is an interesting paper, especially in seeking to bridge the humanistic and mechanistic axis, and the social (soft) sciences and (hard) sciences. In trying to view Hodges' model as a mathematical object (categories, objects, relations ..) and extend the bio-psycho-social model (as needed urgently) of medicine (health and social care) the focus of this paper can help us explore the determinants.

It may be possible using Hodges' model, to identity (isolate) some specific ways in which conceptual models are idealised. They can reveal the nature and extent of situations - compositions, formulations and relationships (scope of practice?), but in practice of course we cannot set a situation* in aspic.


This may be important (essential) when we consider the determinants of health globally (across all the domains of Hodges' model).

Individual

|

      INTERPERSONAL    :     SCIENCES               

HUMANISTIC  --------------------------------------  MECHANISTIC      

 SOCIOLOGY  :    POLITICAL 

|

Group

	Genomics
Social Genomics

*Hodges' model is situated.

To revisit ..